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Nuclear Magnetic Resonance


  • NMR spectroscopy (400-800 MHz) to study samples in solution and observe active nuclei (1H, 13C, 19F, 31P, 113Cd, 195Pt, 29Si, 15N, etc.)
  • HR-MAS: NMR spectroscopy to study samples in gel and tissues

Range of services

  • Structural determination of organic and inorganic compounds (small-medium molecular weight)
  • One- and two-dimensional experiments (COSY, DQFCOSY, TOCSY, HSQC, HMBC, NOESY). DOSY diffusion experiments.
  • Combined experiments such as HMQC-TOCSY and other heteronuclear experiments.
  • Analysis of complex structures (natural products, compounds of biological interest) Multi-dimensional experiments for structural determination in proteins.
  • Combined use of 1H, 13C i 15N for the study of complex molecules such as proteins through two- and threedimensional inverse detection experiments.
  • Implementation of new sequences and methods; methodological development and application.
  • Control of synthesis processes and/or purification of organic compounds. Determination of impurities and minority components; quantitative analyses.
  • HR-MAS experiments for samples in gel or semi-solids; study of metabolites in tissues.
  • Process monitoring, kinetic monitoring; variable temperature experiments.
  • Determination of interactions between proteins and low-molecular weight compounds
  • Work conducted in accordance with standardized procedures (SOP) for the analysis of APIs (USP, European Pharmacopoeia and ASTM standards).
  • Identification of compounds, spectral assignment, reports and evaluations.

Examples of application

  • NMR spectral assignment for the identification of structures.
  • Heparin analysis (in compliance with FDA-USP and European Pharmacopoeia standards).
  • Poloxamer analysis (according to USP procedure).
  • PGLA polymer analysis (in accordance with ASTM standards).
  • Identification analysis for compliance with REACH standard.
  • Study of metabolites resulting from the application of an active ingredient (whether directly or through a prior HPLC system treatment).
  • Quantitative analysis through the use of internal patterns.
  • Determination of the degree of deuteration.
  • Purity studies and studies of the composition of soluble polymers. HR-MAS experiments with tissues.
  • Application of NMR in the analysis of food products (oils, dairy, juices, additives, etc.).
  • Consulting and training for the optimization of the use of existing NMR instrumentation at private centres.


  • Bruker Avance 800 NMR spectrometer (800 MHz) with cryprobe.
  • Bruker Avance 600 NMR spectrometer (600 MHz) with cryprobe.
  • Bruker Avance III 600 NMR spectrometer (600 MHz)
  • Varian Inova-500 NMR spectrometer (500 MHz)
  • Varian VNMRS500 NMR spectrometer (500 MHz)
  • Oxford Instruments HyperSense 52-DNP-5089 hyperpolarizer
  • Bruker DMX-500 NMR spectrometer (500 MHz) with HR-MAS probe
  • Varian VNMRS400 NMR spectrometer (400 MHz)
  • Two Varian Mercury-400 NMR spectrometers (400 MHz)
  • Varian Gemini-300 NMR spectrometer (300 MHz), only 1H, 13C.
Dr. Miguel Feliz Rodenas
Contact person
934 034 464/466
Access Procedures

Any person applying for the first time for any services by CCiTUB must enter as a new user. For this purpose it is necessary to fill in an application form which can be downloaded from The form must be sent to

Assurance of quality

ISO 9001:2008. The CCiTUB have well-established a system of management of the quality based on the ISO norm 9001, which also satisfies the Good Manufacturing Practice requirements (GMP).


Recognition by the Food and Drug Administration as a contract laboratory to perform drug tests.

Acknowledged laboratory Register of Agroalimentary Laboratories of Catalonia.