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A proteome atlas for an untreatable heart disease

As occurs with arteriosclerosis, in which deposits of cholesterol, fat and other substances gradually form plaque in the arteries and constrict blood flow, heart valves can also suffer problems over time. One of the most significant is calcific aortic valve disease (CAVD) which, as its name indicates, consists of the deposition of calcium in the aortic valve of this vital organ.

New osteoarthritis-related biomarkers identified

Osteoarthritis is the most common joint disease. Cartilage, the tissue that normally protects the ends of bones for them to move smoothly over each other and absorbs the shock of movement, wears down over time. This is due to a number of factors such as aging, obesity, joint injury, hereditary causes or performance of activities that overly strain these areas. In the United States, this pathology affects over 27 million people.

2020 might be an achievable horizon by which we can complete the map of the human proteome

When the Human Proteome Project (HPP) was launched in 2010, the scientific community viewed it as “a global initiative to build a map of all human proteins and their involvement in diseases,” says Dr Manuel Fuentes from the Cancer Research Institute of Salamanca.