As occurs with arteriosclerosis, in which deposits of cholesterol, fat and other substances gradually form plaque in the arteries and constrict blood flow, heart valves can also suffer problems over time. One of the most significant is calcific aortic valve disease (CAVD) which, as its name indicates, consists of the deposition of calcium in the aortic valve of this vital organ.
Obesity is a serious public health problem around the world. According to data from the World Health Organization, 39% of people over eighteen are overweight, of which over 650 million were obese in 2016.
Blood cells are considered to be excellent ex vivo models for the characterization of diseases and in the determination of the beneficial or toxic effects of possible treatments. The results of numerous research projects over recent years, through which researchers have developed biomarkers of interest in different pathologies, make up the evidence behind this assertion.
La Cartuja Island, nestled between two arms of the Guadalquivir River in central Seville’s Triana district, is home to some of Spain’s leading research institutes. Denizens like the Doñana Biological Station, the National Center for Accelerators, the Institute for Microelectronics and the Andalusian Molecular Biology and Regenerative Medicine Center all call the Cartuja93 Technological Park home.
Precision medicine applied to breast cancer has traditionally drawn up patient profiles with the use of techniques such as genomic sequencing and microarrays. Over the past decade, proteomics research has achieved breakthroughs in the identification and quantification of certain biomarkers in clinical samples, which help stratify patients by the sub-type of breast cancer that they develop.
Advances in omics technologies have not only made greater quantities of data available for life science research; they have also made it possible to obtain results with greater sensitivity.