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CRISPR-Cas

Screening with CRISPR-Cas: the new life of the molecular scalpel

In 2012, scientists Jennifer Doudna and Emmanuelle Charpentier published an article in Science discussing the possibility of using the CRISPR-Cas system to edit the genome. Their work, supported by Feng Zhang’s later studies, showed that DNA could be quickly, efficiently safely modified thanks to a number of tools discovered in different types of microorganisms, including bacteria and archaea, at the end of the 1980's.